- 24 North Hotel
- Alexander Palms Court
- Almond Tree Inn
- Ambrosia Key West
- Andrews Inn & Garden Cottages
- Authors Key West Guesthouse
- Best Western Hibiscus Motel
- Blue Marlin Motel
- Caribbean House
- Casa 325 Guesthouse
- Casa Marina Key West, Curio Collection by Hilton
- Coco Plum Inn
- Courtney's Place Historic Cottages & Inns
- Courtyard by Marriott Key West Waterfront
- DoubleTree Resort by Hilton Grand Key - Key West
- Douglas House
- Duval House
- Duval Inn - Key West
- Eden House
- El Patio Motel
- Fairfield Inn & Suites by Marriott Key West
- Fairfield Inn & Suites by Marriott Key West at The Keys Collection
- Galleon Resort and Marina
- H2O Suites- Adults Only
- Havana Cabana at Key West
- Heron House - Adult Only
- Heron House Court - Adult Only
- Hilton Garden Inn Key West/The Keys Collection
- Hyatt Centric Key West Resort And Spa
- Hyatt Residence Club Key West, Beach House
- Ibis Bay Resort
- Knowles House B&B
- Kona Kai Oasis
- L'Habitation Guesthouse- Adult Exclusive
- La Concha Key West, Autograph Collection
- La Pensione Inn - Adult Exclusive
- La Te Da - Adult Only, 21 or older
- Marreros Guest Mansion - Adult Only
- NYAH Key West - Adult Exclusive
- New Orleans House
- Ocean Key Resort & Spa
- Oceans Edge Key West
- Old Town Manor
- Opal Key Resort & Marina
- Orchid Key Inn - Adults Only
- Paradise Inn - Adult Exclusive
- Parrot Key Hotel & Villas
- Pegasus International Hotel
- Pier House Resort & Spa
- Santa Maria Suites Resort
- Seascape Tropical Inn
- Seashell Motel and International Hostel
- Silver Palms Inn
- Simonton Court Historic Inn & Cottages
- Smallest Bar Inn
- Southernmost Beach Resort
- Southernmost Point Guest House
- Southwinds Motel
- Suite Dreams Inn by the Beach
- Sunrise Suites Resort
- Sunset Key Cottages
- The Artist House
- The Cabana Inn Key West - Adult Exclusive
- The Capitana Key West
- The Casablanca Hotel
- The Conch House Heritage Inn
- The Curry House
- The Curry Mansion Inn
- The Garden House
- The Gardens Hotel
- The Gates Hotel Key West
- The Grand Guesthouse
- The Guesthouses at Southernmost Beach Resort
- The Inn On Fleming
- The Laureate Key West
- The Mansion on the Sea - Southernmost House in the USA
- The Marker Key West Harbor Resort
- The Marquesa Hotel
- The Palms Hotel
- The Perry Hotel & Marina Key West
- The Porch on Frances Inn - Adults Exclusive
- The Reach Key West, Curio Collection by Hilton
- The Saint Hotel Key West, Autograph Collection
- The Southernmost Inn-Adults Only
- Truman Hotel
- Weatherstation Inn Circa 1911
- Westwinds Inn
- Wicker Guesthouse